RFC 4840 Multiple

Federal panel aims to improve health care.

Problem Statement for Default Address Selection in Multi-Prefix Environments: Operational Issues of RFC 3484 Default Rules

A single physical link can have multiple prefixes assigned to it. In that environment, end hosts might have multiple IP addresses and be required to use them selectively. RFC 3484 defines default source and destination address selection rules and is implemented in a variety of OSs. But, it has been too difficult to use operationally for several reasons. In some environments where multiple prefi...

Proposing New Algorithm for Modeling of Regenerative Fuel Cell (RFC) System

Regenerative Fuel Cell (RFC) systems are used for the enhancement of sustainable energy aspect in conventional fuel cells. In this study, a photovoltaic-electrolyzer-fuel cell integrated cycle has been presented. The proposed system has been designed as a novel approach for alleviating the restrictions  on energy streams in the RFC systems. Modeling of the system has been performed from the mas...

Coexistence of multiple mechanisms of PT523-resistance in human leukemia cells harboring three reduced folate carrier alleles: transcriptional silencing, inactivating mutations and allele loss

The reduced folate carrier (RFC) is the dominant route for the uptake of various antifolates including PT523, a potent dihydrofolate reductase inhibitor (Ki=0.35 pM) and an excellent transport substrate of the RFC (Kt =0.7 μM). Herein we describe the multiple mechanisms of RFC inactivation in human leukemia PT523-resistant cells originally harboring three RFC alleles. Cellular exposure to gradu...

Coexistence of multiple mechanisms of PT523 resistance in human leukemia cells harboring 3 reduced folate carrier alleles: transcriptional silencing, inactivating mutations, and allele loss.

The reduced folate carrier (RFC) is the dominant route for the uptake of various antifolates including PT523, a potent dihydrofolate reductase inhibitor (Ki = 0.35 pM) and an excellent transport substrate of the RFC (Kt = 0.7 microM). Here, we describe the multiple mechanisms of RFC inactivation in human leukemia PT523-resistant cells originally harboring 3 RFC alleles. Cellular exposure to gra...